張宗康 博士

履歷(教育及工作經驗)

教育：

1. 2005 上海復旦大學醫學院臨床醫學學士
2. 2007 上海復旦大學醫學院臨床醫學碩士
3. 2013 香港理工大學康復治療科學系博士

工作經驗：

1. 2005-2007 上海華山醫院手外科實習醫生
2. 2008-2008 香港理工大學康復治療科學系研究助理
3. 2010-2011 美國紐約石溪大學生物醫學工程訪問學者
4. 2011-2013 香港理工大學康復治療科學系兼職副研究員
5. 2013-2014 香港中文大學中醫學院研究助理
6. 2014-2017 香港中文大學中醫學院博士後研究員
7. 2017-2019 香港中文大學中醫學院副研究員
8. 2019至今 香港中文大學中醫學院研究助理教授

科研範圍

1. 針對腫瘤及肌肉骨骼系統疾病的分子機理探索及基於中醫藥天然產物和適配子的藥物開發研究
2. 天然產物轉化研究
3. 基於適配子的組織靶向藥物遞送

著作及論文（選列)

1. Chen Z, Zhang N, Chu HY, Yu Y, Zhang ZK*, Zhang G, Zhang BT. Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery. Front Cell Dev Biol 2020;8:593269. DOI:10.3389/fcell.2020.593269.
2. Zheng Y, Wang X, Zhang ZK#, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang BT, Zhang G, Lu A. Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial. Sci Rep 2019;9(1):2089. DOI:10.1038/s41598-018-38335-3.
3. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT. Long Noncoding RNA lncMUM
A Reverses Established Skeletal Muscle Atrophy following Mechanical Unloading. Mol Ther 2018;26(11):2669-80. DOI:10.1016/j.ymthe.2018.09.014.
4. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT. A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. J Cachexia Sarcopenia Muscle 2018;9(3):613-26. DOI:10.1002/jcsm.12281.
5. Liang C, Li F, Wang L, Zhang ZK#, Wang C, He B, Li J, Chen Z, Shaikh AB, Liu J, Wu X, Peng S, Dang L, Guo B, He X, Au DWT, Lu C, Zhu H, Zhang BT, Lu A, Zhang G. Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma. Biomaterials 2017;147:68-85. DOI:10.1016/j.biomaterials.2017.09.015.
6. Zhang ZK, Guo X, Lao J, Qin YX. Effect of capsaicin-sensitive sensory neurons on bone architecture and mechanical properties in the rat hindlimb suspension model. J Orthop Translat 2017;10:12-7. DOI:10.1016/j.jot.2017.03.001.
7. Guo B, Zhang ZK#, Liang C, Li J, Liu J, Lu A, Zhang BT, Zhang G. Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism. Calcif Tissue Int 2017;100(2):184-92. DOI:10.1007/s00223-016-0209-4.
8. He B, Zhang ZK#, Liu J, He YX, Tang T, Li J, Guo BS, Lu AP, Zhang BT, Zhang G. Bioinformatics and Microarray Analysis of miRNAs in Aged Female Mice Model Implied New Molecular Mechanisms for Impaired Fracture Healing. Int J Mol Sci 2016;17(8):E1260. DOI:10.3390/ijms17081260.
9. Zhang ZK, Li J, Liu J, Guo B, Leung A, Zhang G, Zhang BT. Icaritin requires Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal muscle atrophy following mechanical unloading. Sci Rep 2016;6:20300. DOI:10.1038/srep20300.
10. Zhang ZK, Li J, Yan DX, Leung WN, Zhang BT. Icaritin Inhibits Collagen Degradation-Related Factors and Facilitates Collagen Accumulation in Atherosclerotic Lesions: A Potential Action for Plaque Stabilization. Int J Mol Sci 2016;17(2):E169. DOI:10.3390/ijms17020169.