張保亭 教授 詳情

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  期刊論文Journal Paper

 
  1. Liu J, Liang C, Guo B, Wu X, Li D, Zhang Z, Zheng K, Dang L, He X, Lu C, Peng S, Pan X, Zhang BT*, Lu A, Zhang G. Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. Aging Cell. 2017 Jan 13. doi: 10.1111/acel.12566.
  2. He B, Zhang ZK, Liu J, He YX, Tang T, Li J, Guo BS, Lu AP, Zhang BT*, Zhang G. Bioinformatics and Microarray Analysis of miRNAs in Aged Female Mice Model Implied New Molecular Mechanisms for Impaired Fracture Healing. International Journal of Molecular Sciences 2016; 17(8): E1260.
  3. Li D, Liu J, Guo B, Liang C, Dang L, Lu C, He X, Cheung HY, Xu L, Lu C, He B, Liu B, Shaikh AB, Li F, Wang L, Yang Z, Au DW, Peng S, Zhang Z, Zhang BT, Pan X, Qian A, Shang P, Xiao L, Jiang B, Wong CK, Xu J, Bian Z, Liang Z, Guo DA, Zhu H, Tan W, Lu A, Zhang G. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nature Communications 2016; 7:10872.
  4. Zhang ZK, Li J, Liu J, Guo B, Leung A*, Zhang G*, Zhang BT*. Icaritin requires Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal muscle atrophy following mechanical unloading. Scientific Reports 2016; 6:20300.
  5. Zhang ZK, Li J, Yan DX, Leung WN*, Zhang BT*. Icaritin Inhibits Collagen Degradation-Related Factors and Facilitates Collagen Accumulation in Atherosclerotic Lesions: A Potential Action for Plaque Stabilization. International Journal of Molecular Sciences 2016; 17(2): E169.
  6. Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials 2015; 52:148-60.
  7. Fu X, Xiao J, Wei Y, Li S, Liu Y,Yin J, Sun K, Sun H, Wang H, Zhang Z, Zhang BT, Sheng C, Wang H, Hu P. Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion. Cell Research 2015; 25(6): 655-73,.
  8. He YX, Liu J, Guo B, Wang Y, Pan X, Li D, Tang T, Chen Y, Peng S, Bian Z, Liang Z, Zhang BT*, Lu AP, Zhang G. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. Scientific Reports 2015; 5:8856.
  9. Liang C, Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DWT, Pan X, Zhang BT, Lu C, Zhang H, Yue KM, Qian A, Shang P, Xu JK, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L, Lu AP, Zhang G. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nature Medicine 2015; 21(3):288-94.
  10. Wang X, Ip M, Leung AW, Yang Z, Wang P, Zhang BT, Ip S, Xu C. Sonodynamic action of curcumin on foodborne bacteria Bacillus cereus and Escherichia coli. Ultrasonics 2015; 62:75-9.
  11. Guo B, Zhang BT*, Zheng L, Tang T, Liu J, Wu H, Yang Z, Peng S, He X, Zhang H, Yue KM, He F, Zhang L, Qin L, Bian Z, Tan W, Liang Z, Lu A, Zhang G. Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation. Bone 2014; 59:76-88.
  12. Zhang BT, Yeung SS, Cheung KK, Chai ZY, Yeung EW. The adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth. Muscle Nerve 2014, 49(5):691-9.
  13. Peng S, Zhang G, Zhang BT*, Guo B, He Y, Bakker AJ, Pan X, Zhen W, Hung L, Qin L, Leung WN. The beneficial effect of Icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats. Bone 2013; 55(1):230-40.
  14. Zhang BT, Whitehead NP, Gervasio OL, Reardon TF, Vale M, Fatkin D, Dietrich A, Yeung EW, Allen DG. Pathways of Ca2+ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle. Journal of Applied Physiology 2012; 112(12):2077-86.
  15. Zhang G, Guo B, Wu H, Tang T, Zhang BT, Zheng L, He Y, Yang Z, Pan X, Chow H, To K, Li Y, Li D, Wang X, Wang Y, Lee K, Hou Z, Dong N, Li G, Leung K, Hung L, He F, Zhang L, Qin L. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine 2012; 18(2): 307-314.
  16. Guo BS, Cheung KK, Yeung SS, Zhang BT, Yeung EW. Electrical stimulation influences satellite cell proliferation and apoptosis in unloading-induced muscle atrophy in mice. PLoS One 2012; 7(1): e30348.
  17. Zhang BT, Yeung SS, Liu Y, Wang HH, Wan YM, Ling SK, Zhang HY, Li YH, Yeung EW. The effects of low frequency electrical stimulation on satellite cell activity in rat skeletal muscle during hindlimb suspension. BMC Cell Biology 2010; 11: 87.
  18. Allen DG, Zhang BT, Whitehead NP. Stretch-Induced Membrane Damage in Muscle: Comparison of Wild-Type and mdx Mice. Adv Exp Med Biol 2010; 682: 297-313.
  19. Zhang BT, Yeung SS, Allen DG, Qin L, Yeung EW. Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions. Journal of Applied Physiology 2008; 105(1): 352-7.
  20. 張保亭,張戈,秦嶺.中藥仙靈骨葆對絕經後骨質疏鬆症腸鈣吸收障礙的影響.中國中藥雜誌 37(22): 3506-8, 2012.
  21. 黃偉哲,肖大偉,張保亭,宋銀子,龐雅軒,楊默.比較麻醉和清醒狀態對高頻超聲心動圖評價小鼠心功能影響的研究.中華超聲影像學雜誌 2006; 15: 128-31.
  22. 張保亭*,顏乾麟,顏德馨,李智,于永春,黃國平,湯德生,葉新.穩斑護脈顆粒對動脈粥樣硬化斑塊穩定性影響的分子機制.中國中西醫結合雜誌 2005; 25: 154-9.
  23. 張保亭*,顏乾麟,顏德馨,胡泉林.急性冠狀動脈綜合征不同證候病變血管數、血管狹窄程度、 Braunwald積分比較及相關性研究.中國中醫急症 2005; 14: 147-9.
  24. 張保亭*,顏乾麟,顏德馨,胡泉林.106例急性冠狀動脈綜合征患者證候分佈特點研究. 中醫雜誌 2005; 46: 529-32.
  25. 魏鐵力,鄧聰,陳勇鳴,張小燕,張保亭,王宇鋒.祛風活血治頭痛. 上海中醫藥雜誌 2005; 39(2): 31-2.
  26. 董福輪,季蓓,張保亭,韓天雄,任敏之.腦福音治療硬腦膜下血腫25例分析.中華實用中西醫雜誌 2005; 18: 170-71.
  27. 董福輪,季蓓,張保亭,張小燕,韓天雄.自擬瀉福音治療潰瘍性結腸炎55例的臨床觀察.中華實用中西醫雜誌 2004; 17: 3568-9.
  28. 魏鐵力,王宇鋒,陳勇鳴,張小燕,張保亭. 內外同修治頭痛.同濟大學學報(醫學版)2004; 25: 55-7.
  29. 張保亭*.抗動脈粥樣硬化中藥的研究進展.中國中西醫結合雜誌 2003; 23: 394-8.
  30. 活血化瘀法的經驗. 中醫雜誌 2003; 44: 15-6.
  31. 張保亭*.骨疏康對去卵巢雌鼠骨質疏鬆症防治作用的研究.中國骨腫瘤骨病 2002; 1: 283-6.
  32. 張保亭*.顏德馨教授治療冠心病經驗介紹. 新中醫 2002; 34: 8-9.
  33. 邢斌,趙昊龍,張保亭. 顏亦魯救治急重症驗案2則. 新中醫 2002; 34: 61.
  34. 邢斌,虞曙東,趙昊龍,張保亭,魏鐵力.顏德馨教授運用川芎心法.四川中醫 2002; 20: 6-7.
  35. 邢斌,趙昊龍,張保亭.顏德馨教授妙用膏方治療冠心病特色探析.中醫藥學刊 2002; 20: 6-7.
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     會議論文Conference Paper

  1. Wong KY, Liang C, Zhang ZK, Li J, Leung WN, Zhang G, Zhang BT*. The effect of chalcone derivative on BMP-mediated signaling, osteogenic differentiation and calcium deposition in vitro. The IBMS Herbert Fleisch Workshop, February 28-March 1, 2016, Belgium.
  2. Zhang BT*. Research and Development of Natural Products for Musculoskeletal Diseases. The Sixth Pan-Pacific Nursing Conference and First Colloquium on Chronic Illness Care. 2-4 March, 2016, Hong Kong. (Plenary speaker)
  3. Liu J, Guo BS, Zhang ZK, Zhang BT, Lu AP, Zhang G. Increased Plekho1 within osteoblast suppresses BMP signaling to inhibit bone formation during aging. WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, April 14-17, 2016, Malaga, Spain. Osteoporosis International 27 (Suppl 1): S368-S369.
  4. Liu J, Lv C, Guo B, Li D, Liang C, Pan X, Zhang L, Zhang BT, Lu A, Zhang G. Highly expressed CKIP-1 inhibits BMP signaling pathway to suppress osteogenic differentiation and mineral deposition in osteoblast during glucocorticoid treatment in vitro. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, October 8-12, 2015, Seattle, USA.
  5. Liu J, Zhang Z, Li J, Guo B, Zhang BT, Lu A, Zhang G. Targeting CKIP-1 within osteoblast: A potential anabolic strategy for bone formation reduction during aging? American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, October 8-12, 2015, Seattle, USA.
  6. Liang C, Xu M, Zhou X, Wang K, Xu J, Zhang BT, Lu A, Zhang G. Discovery of Small Molecules to Promote BMP Signaling and Bone Formation. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, October 8-12, 2015, Seattle, USA.
  7. Zhang ZK, Li J, Leung WN, Zhang G, Zhang BT*. Icaritin requires Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal muscle atrophy following mechanical unloading. The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine, July 22-24, 2015, Singapore.
  8. Li J#, Zhang ZK, Qu Y, Leung WN, Zhang BT*. Anti-inflammation and anti-fibrosis actions of resveratrol on experimental pneumoconiosis. The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine, July 22-24, 2015, Singapore. ( # Young Scientist Poster Presentation Award)
  9. Guo B, Lu A, Zhang BT, Zhang G. Therapeutic inhibition of miR-214 by (AspSerSer)6-liposome encapsulating antagomir-214 in osteoblast cells for promoting bone formation in aged osteoporotic rats. 2015 Orthopaedic Research Society (ORS) annual meeting, March 28-31, 2015, Las Vegas, USA.
  10. Lv C, Liu J, Guo B, Li D, Liang C, Zhang BT, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 expression and decreased phosphorylated Smad1/5 within osteoblasts during bone formation reduction in glucocorticoid-induced osteoporotic rats. 2015 Orthopaedic Research Society (ORS) annual meeting, March 28-31, 2015, Las Vegas, USA.
  11. Liu J, Guo B, Li D, Liang C, Dang L, He X, Zhang BT, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 within osteoblast suppresses BMP signaling to inhibit bone formation during aging. 2015 Orthopaedic Research Society (ORS) annual meeting, March 28-31, 2015, Las Vegas, USA.
  12. Guo BS, Liang C, Pan XH, Zhang LQ, Lu A, Zhang BT, Zhang G. Up-regulated CKIP-1 expression within osteoblasts associates with reduced BMP signaling and decreased bone formation during aging. 7th International Conference on Osteoporosis and Bone Research, October 16-19, 2014, Xiamen, China.
  13. Guo BS, Liu J, Wu H, Dang L, Zhang LQ, Lu A, Zhang BT, Zhang G. Therapeutic silencing intra-osseous Ckip-1 for promoting bone formation in an aged rat model of male osteoporosis. ASBMR 2014 Annual Meeting, September 12-15, 2014, Houston, Texas, USA.
  14. Peng S, Zhang G, Zhang BT*, Guo B, He Y, Bakker AJ, Pan X, Zhen W, Hung L, Qin L, Leung WN. The beneficial effect of Icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats. The 55th Annual American Society of Pharmacognosy meeting, August 2-6, 2014, Oxford, Mississippi, USA.
  15. Zhang ZK, Leung WN, Zhang G, Li J, Zhang BT*. The effect of icaritin on skeletal muscle atrophy following mechanical unloading. The 55th Annual American Society of Pharmacognosy meeting, August 2-6, 2014, Oxford, Mississippi, USA.
  16. Li J, Zhang BT*, Qu Y, Zhang ZK, Leung WN. Anti-inflammation and anti-fibrosis actions of resveratrol on in vitro pneumoconiosis model. The 55th Annual American Society of Pharmacognosy meeting. August 2-6, 2014, Oxford, Mississippi, USA.
  17. Baosheng Guo, Liu Jin, Dang lei, Liang Chao, Xiaohua Pan, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Up-regulated CKIP-1 expression within osteoblasts associates with reduced BMP signaling and decreased bone formation during aging. 5th Sino-American Symposium on Clinical and Translational Medicine (SAS-CTM), June 21-22, 2014, Beijing, China.
  18. Guo BS, Liu J, Wu H, Zhang LQ, Qin L, Lu A, Zhang BT, Zhang G. Ckip-1 in osteoblasts plays an inhibition role in bone formation in aged male osteoporosis. Molecular Therapy Vol. 22. Suppl.1 S39-S40. American Society of Gene & Cell Therapy 17th Annual Meeting, May 21-24, 2014, Washingon DC. USA.
  19. Guo BS, Lu A, Zhang BT, Zhang G. Inhibition of miR-214 by (Asp-Ser-Ser)6-liposome capsulated antagomiR-214 in osteogenic cells of aged osteoporotic rats: Quantification analysis for expression levels of miR-214, osteocalcin mRNA and ATF4 protein in osteogenic cells. 2014 American Orthopaedics Society Annual Meeting, March 15-18, 2014, New Orleans, Louisiana, USA.
  20. Guo BS, Wu H, Zhang LQ, Qin L, Lu A, Zhang BT, Zhang G. Therapeutic silencing intra-osseous Plekho1 for promoting bone formation in a rat model of aged postmenopausal osteoporosis. 2014 American Orthopaedics Society Annual Meeting, March 15-18, 2014, New Orleans, Louisiana, USA.
  21. Guo BS, Wang X, Hong A, Lu A, Zhang BT, Zhang G. Therapeutic inhibition of miR-214 within osteogenic cells in aged osteoporotic rats induced by ovariectomy for bone anabolic strategy: Optimization of dosage and duration. Bone Joint J 2014 vol. 96-B no. SUPP 11. 8th Combined Meeting of Orthopaedic Research Societies. October 13-16, 2013, San Servolo Venice, Italy.
  22. Zhang BT*, Leung WN, Li J. Anti-inflammation and anti-fibrosis actions of resveratrol on in vitro pneumoconiosis model. HK-Swiss Mini Symposium on Traditional Chinese Medicine. July 3-4, 2013, Hong Kong, China. (Invited speaker)
  23. Guo BS, Wang X, Hong A, Lu A, Zhang BT, Zhang G. Therapeutic silencing intra-osseous PLEKHO1 for promoting bone formation in a rat model of aged postmenopausal osteoporosis. RNAi China, 2013, June 20-22, 2013, Kunshan, China.
  24. Zhang BT*. Introduction of Prof. Yan Dexin's therapeutic methods with Chinese medicine in cardiovascular diseases. The Second Annual Academic Conference of the World Federation of Chinese Medicine Societies Specialty Committee of the Internal Medicine. March 9, 2013, Hong Kong, China. (Invited speaker)
  25. Guo BS, Zhang BT, Wang J, Liang C, Wu H, Yang Z, Chow HL., Hou Z, Huang Y, He F, Qin L, Zhang L, Bian Z, Lu A, Zhang G. (Asp-Ser-Ser)6 facilitates bone anabolic siRNA specifically targeting osteogenic cells in aged ovariectomized rats. 2013 Orthopaedics Research Society Annual Meeting, January 26–29, 2013, San Antonio, Texas, USA.
  26. Zhang BT*, Leung WN, Guo BS, Yeung EW, Yeung SS, Qin L, Zhang G. Introduction to sarcopenia and interventions research. Hong Kong International Integrative Medicine Conference 2012, July 6-8, 2012, Hong Kong, China. (Invited Speaker)
  27. Wu H, Guo B, Zhang BT, Liang C, Yang Z, Hou Z, Qin L, Zhang G. A drug delivery system for 'musculoskeleton strengthening herbs' for approaching bone formation surfaces. European Congress on Osteoporosis & Osteoarthritis (IOF-ECCEO12) Poster Presentation Abstracts P525, Osteoporosis Int (2012) 23 (Suppl 2): S293.
  28. Zhang BT, Guo BS, He YX, Leung WN, Qin L, Zhang G. Icaritin exerts beneficial effect on skeletal muscle independent of estrogen receptor pathway in rats with established osteoporosis induced by ovariectomy. ASBMR 2011 Annual Meeting, September 16-20, 2011, San Diego, California, USA. Journal of Bone and Mineral Research 26(supplement): S236 ( President's Poster Competition Award )
  29. Zhang G, Guo B, Wu H, Tang T, Zhang BT, Hung L, He F, Zhang L, Qin L. A delivery system specifically approaching bone formation surfaces to facilitate translating RNAi-based anabolic therapy. ASBMR 2011 Annual Meeting, September 16-20, 2011, San Diego, California, USA. Journal of Bone and Mineral Research 26(supplement):S8
  30. Guo B, Zhang BT, Wu H, Tang T, He Y, Li G, Hung L, He F, Zhang L, Qin L, Zhang G. Therapeutic RNAi targeting CKIP-1 for promoting bone formation in an aged rat model of postmenopausal osteoporosis. ASBMR 2011 Annual Meeting, September 16-20, 2011, San Diego, California, USA. Journal of Bone and Mineral Research 26(supplement): S7
  31. Wu H, Tang T, Guo BS, Zhang BT, Yang ZJ, Hung L, Shao NS, Zhang LQ, Qin L, Zhang G. Aptamer-Functionalized Stable Nucleic Acid Lipid Particles for siRNA Cell-specific Delivery to Osteoblast Cells. ASBMR 2011 Annual Meeting, September 16-20, 2011, San Diego, California, USA. Journal of Bone and Mineral Research 26(supplement):S304
  32. Wan Q, Guo BS, Zhang BT, Cheung KK, Yeung EW, Yeung SS. Low-frequency electrical stimulation enhances satellite cell activity in skeletal muscle atrophy. The 5th World Congress of the International Society Physical & Rehabilitation Medicine, June 13-17, 2009, Istanbul, Turkey.
  33. Zhang BT, Au DWT, Yeung SS, Yeung EW. Vacuolization of sarcoplasmic reticulum and mitochondria following eccentric contractions in mouse skeletal muscle. 4th World Congress of the International Society of Physical and Rehabilitation Medicine, June 10-14, 2007, Soeul, Korea. pp. 116-7.
  34. Yeung SS, Zhang BT, Yeung EW. Effect of electrical stimulation on skeletal muscle function and dystrophin following hindlimb unloading. 4th World Congress of the International Society of Physical and Rehabilitation Medicine, June 10-14, 2007, Soeul, Korea. pp. 323.
  35. Yeung EW, Zhang BT, Au DWT, Yeung SS. Ultrastructure of the t-tubular system in dystrophic muscles following eccentric contractions. 4th World Congress of the International Society of Physical and Rehabilitation Medicine, June 10-14, 2007, Soeul, Korea. pp. 105.
  36. Zhang BT, Liu Y, Wang HH, Wan YM, Ling SK, Zhang HY, Yeung SS, Li YH, Yeung EW. Mechanical unloading of skeletal muscle suppresses satellite cell proliferative activity. 16th Humans in Space Symposium of the International Academy of Astronautics, May 20-24, 2007, Beijing, China. pp. 206.
  37. Yeung EW, Zhang BT, Yeung SS, Liu Y, Wang HH, Wan YM, Ling SK, Zhang HY, Li YH. Effect of low frequency electrical stimulation on satellite cell activity in rat muscles following hindlimb unloading. 16th Humans in Space Symposium of the International Academy of Astronautics, May 20-24, 2007, Beijing, China. pp. 208.
  38. Zhang BT, Yeung SS, Yeung EW. The role of calcium-calpain pathway in the damage of muscle cytoskeleton after eccentric contractions. The 5th Pan-Pacific Conference on Rehabilitation, June 9-11, 2006, Hong Kong, pp. 45.
  39. Zhang BT, Yeung SS, Yeung EW. Calcium induced the damage of cytoskeleton after eccentric contractions. 13th Commonwealth International Sport Conference, March 9-12, 2006, Melbourne, Australia, pp. 50.
  40. Zhang BT*. Study on the prevention and treatment of osteoporosis in ovariotomized rat with GuShuKang granule. 2002 International Osteoporosis Conference, October 20, 2002, Shanghai, China. (The 1st Award, GUSHUKANG Outstanding Research Paper)
 

     著作章節Book Chapters

  1. 楊世模,張保亭,郭保生,萬青.骨骼肌生物力學. In: 肌肉骨骼系統基礎生物力學 (ISBN 978-7-117-10602-3), 主編: 鄺適存, 郭霞.人民衛生出版社, 第三版, 頁碼: 99-114, 2008.
  2. 張保亭. 鬱症中醫治療. In: 顏德馨中醫心腦病診治精粹 (ISBN 978-7-117-08118-4). 主編:顏乾麟.人民衛生出版社, 頁碼: 416-425, 2006.
  3. 張保亭. 衡法抗衰老、防治老年病的科研成果. In: 氣血與長壽 (ISBN 7-5439-2101-4), 主編:顏德馨. 上海科學技術文獻出版社,第二版,頁碼: 200-235, 2003.
  4. 張保亭. 腎、膀胱系疾病的自診自療. In: 常見病的中醫自診和調治 (ISBN 7-5320-8206-7), 主編: 顏德馨,餘小萍. 上海教育出版社, 頁碼:151-212, 2002.