陳俊偉 博士 詳情

 

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期刊論文 Journal Papers

 
  1. Han L, Lu X, Wang M, Gan D, Deng W, Wang K, Fang L, Liu K, Chan CW, Tang Y, Weng LT, Yuan H. A Mussel-Inspired Conductive, Self-Adhesive, and Self-Healable Tough Hydrogel as Cell Stimulators and Implantable Bioelectronics. Small 2017 Jan;13(2). doi: 10.1002/smll.201601916.
  2. Chau DK, Choi AY, Yang W, Leung WN, Chan CW*. Downregulation of Glutamatergic and GABAergic Proteins in Valproic Acid associated Social Impairment during Adolescence in Mice. Behavioural Brain Research. 2017 Jan 1; 316: 255–260.
  3. Huan T, Xian JW, Leung WN, Li L, Chan CW*. Cerebrospinal Fluid Metabolomics after Natural Product Treatment in an Experimental Model of Cerebral Ischemia. OMICS: A Journal of Integrative Biology. 2016 Nov;20(11):670-680.
  4. Zhang Z, Leung WN, Li G, Lai YM, Chan CW*. 2016. Osthole Promotes Endochondral Ossification and Accelerates Fracture Healing in Mice. Calcified Tissue International. 2016 99(6), 649-660.
  5. Xie C, Lu X, Wang K, Yuan H, Fang L, Zheng X, Chan CW, Ren F, Zhao C. 2016 Pulse Electrochemical Driven Rapid Layer-by-Layer Assembly of Polydopamine and Hydroxyapatite Nanofilms via Alternative Redox in Situ Synthesis for Bone Regeneration. ACS Biomater. Sci. Eng., 2016, 2 (6), pp 920–928
  6. Wang Z, Dong L, Han L, Wang K, Lu X, Fang L, Qu S, Chan CW. 2016. Self-assembled Biodegradable Nanoparticles and Polysaccharides as Biomimetic ECM Nanostructures for the Synergistic effect of RGD and BMP-2 on Bone Formation. Sci Rep. 2016 Apr 28;6:25090.
  7. Xian JW, Choi AYT, Lau CBS, Leung WN, Ng CF, Chan CW*. 2016. Gastrodia-Uncaria Water Extract Exerts Antioxidative and Antiapoptotic Effects Against Cerebral Ischemia in vitro and in vivo. Chinese Medicine. 2016 May 31, 11 :27. doi: 10.1186/s13020-016-0097-6.
  8. Zhang Z, Leung WN, Cheung HY, Chan CW*. 2015. Osthole: A Review on its Bioactivities, Pharmacological Properties and Potential as Alternative Medicine. Evidence-Based Complementary and Alternative Medicine. 2015:919616.
  9. Dan X, Wong JH, Fang EF, Chan CW, Ng TB. Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans. J Agric Food Chem. 2015 Apr 22;63(15):3903-14.
  10. Luk HK, Lai YM, Qin L, Chan CW, Liu Z, Huang YP, Zheng YP. 2011. Ultrasonic Evaluation of Bone Callus Growth in a Rabbit Tibial Distraction Model. International Conference of Biomedical Engineering Systems and Technologies, 28-30 Sept. 2011 Singapore, World Academy of Science, Engineering and Technology. 81: 317-324.
  11. Hui FF, Chan CW, Yeung HY, Lee KM, Qin L, Li G, Hu YY, Cheng JC. 2011. Low intensity pulsed ultrasound enhances posterior spinal fusion implanted with mesenchymal stem cells-calcium phosphate composite without bone grafting. Spine 36(13):1010-1016.
  12. He YX, Zhang G, Pan XH, Liu Z, Zheng LZ, Chan CW, Lee KM, Cao YP, Li G, Wei L, Hung LK, Leung KS, Qin L. 2011. Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model. Bone 48(6):1388-1400.
  13. Wang HH, Wang YX, Griffith JF, Sun YL, Zhang G, Chan CW, Qin L, Ahuja AT, Teng LS. 2009. Pitfalls in interpreting rat knee joint magnetic resonance images and their histological correlation. Acta Radiologica 28:1-7.
  14. 倪明 , 謝慧琪 , 陳俊偉 , 楊志明 , 秦嶺 , 李剛. 利用旋轉式生物反應器快速擴增骨髓間充質干細胞. 醫用生物力學 2009年2月第24卷第1期·66-71. (Rapid expansion of bone marrow derived mesenchymal stem cell (MSCs) using rotary bioreactor. Journal of Medical Biomechanics 2009. 24(1):66-71.
  15. Zhou XZ, Zhang G, Dong QR, Chan CW, Liu CF, Qin L. 2009. Low-dose X-irradiation promotes mineralization of fracture callus in a rat model. Arch Orthop Trauma Surg. 129(1):125-132.
  16. Chan CW, Hui CFF, Pan WM, Lee KM, Qin L, Hu YY, Leung KS, Cheng JCY. 2008 Enhancement of low intensity pulsed ultrasound on spinal fusion augmented with stem cell-bioceramic composite. Studies in health technology and informatics. 140: 361.
  17. 秦嶺, 張戈, 盛輝, 楊家威, 楊曉恩, 陳俊偉, 張穎凱, 高士進,梁國穗. 現代生物影像方法評價脂多糖與甲基強的松龍聯合誘導的實驗性骨壞死. 中國修復重建外科雜誌2008年3月第22卷第3期·258-264. Qin L, Zhang G, Sheng H, Yeung KW, Yeung HY, Chan CW, Cheung WH, Griffith J, Leung KS. Multiple Bioimaging modalities in evaluation of an experimental osteonecrosis model induced by a combination of lipopolysaccharide and methylprednisolone. Chinese Journal of Reparative and Reconstructive Surgery, March 2008, Vol. 22, No.3 pp258-264.
  18. Chan CW, Qin L, Lee KM, Yeung HY, Hu YY, Wong KHK, Yip RCL, Cheng JCY. 2007. Bio-engineered mesenchymal stem cell-tricalcium phosphate ceramics composite augmented bone regeneration in posterior spinal fusion. Key Engineering Materials. 334-335:1201-1203.
  19. Chan CW, Wong KHK, Lee KM, Qin L, Fan HB, Hu YY, Cheng JCY. 2007. Can basic fibroblast growth factor pre-treatment enhance mesenchymal stem cell therapy in undecorticated posterior spinal fusion? Key Engineering Materials. 330-332:1137-1140.
  20. Chan CW, Lee KM, Qin L, Wong KHK, Fan HB, Hu YY, Cheng JCY. 2007. Mesenchymal stem cell derived osteogenic cells is superior to bone marrow aspirate impregnated biomaterial complex in posterior spinal fusion. Key Engineering Materials. 330-332:1149-1152.
  21. Sheng H, Zhang G, Cheung WH, Chan CW, Wang YX, Lee KM, Wang HF, Leung KS, Qin L. 2007. Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development. Journal of Orthopaedic Surgery and Research. 2:15.
  22. Zhang G, Qin L, Sheng H, Yeung KW, Yeung HY, Cheung WH, Griffith J, Chan CW, Leung KS. 2007. Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits through inhibition of both thrombosis and lipid-deposition. Bone 40(3):685-692.
  23. Sheng H, Zhang G, Cheung WH, Chan CW, Lee KM, Wang HF, Leung KS, Qin L. 2007. The temporal change of bone marrow fat cells in the process of steroid-associated osteonecrosis development. Chinese Journal of Osteoporosis. 13(8): 547-550. (盛輝, 張戈, 張穎愷, 陳俊偉, 李廣文, 王洪複, 梁國穗 ,秦 嶺. 2007骨髓脂肪細胞在激素性骨壞死發生過程中的時序變化特點. 中國骨質疏鬆雜誌 13(8): 547-550)
  24. Chan CW, Qin L, Lee KM, Zhang M, Cheng JCY, Leung KS. 2006. Low intensity pulsed ultrasound accelerated bone remodeling during consolidation stage of distraction osteogenesis. Journal of Orthopaedic Research 24(2):263-270.
  25. Chan CW, Qin L, Lee KM, Cheung WH, Cheng JCY, Leung KS. 2006. Dose-dependent effect of low intensity pulsed ultrasound on callus formation during rapid distraction osteogenesis. Journal of Orthopaedic Research 24(11):2072-2079.
  26. Qin L, Zhang G, Sheng H, Yeung KW, Yeung HY, Chan CW, Cheung WH, Griffith J, Chiu KH. 2006. Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipolysaccharide and methylprednisolone. Bone 39(4): 863-871.
  27. Chan CW, Yeung HY, Lee KM, , Chiu YM, Guo X, Chow P, Tabata Y, Cheng J. 2005. Temporal and spatial expression pattern of VEGF and VEGF receptor in the posterior spinal fusion with allograft. Key Engineering Materials 288-289: 491-494.
  28. Lu X, Leng Y, Zhang XD, Xu JR, Qin L, Chan CW. 2005. Comparative study of osteoconduction on micromachined and alkali-treated titanium alloy surfaces in vitro and in vivo. Biomaterials 26(14):1793-1801.
  29. Qin L, Chan CW, Fu LK, Leung KS. 2003. Bone to bone repair and bone to tendon healing in patella- patellar tendon complex— a comparative study in rabbits. Journal of Medical Biomechanics. 18(2): 65-70. (秦嶺 , 陳俊偉, 符立勤, 梁國穗 2003 兔髕骨- 髕腱復合體中骨- 骨愈合和骨-腱愈合的比較研究. 醫用生物力學18(2): 65-70.)
  30. Leung KS, Qin L, Fu LK, Chan CW. 2002. A comparative study of bone repair and bone to tendon healing in patella-patella tendon complex in rabbits. Clinical Biomechanics 17: 594-602.
  31. Cheng JC, Tang SP, Guo X, Chan CW, Qin L. 2001. Osteopenia in Adolescent Idiopathic Scoliosis: A histomorphometic study. Spine 26(3):E19-E23
  32. Leung KS, Lee KM., Chan CW, Mak A, Fung KP. 2000. Mechanical characterisation of regenerated osseous tissue during callotasis and related biological phenomenon. Life Sciences. 66(4):327-336.
  33. Suen YK, Fung KP, Choy YM, Lee CY, Chan CW, Kong SK. 2000. Concanavalin A induced apoptosis in murine macrophage PU5-1.8 cells through clustering of mitochondria and release of cytochrome c. Apoptosis. 5:369-377.
  34. Qin L., Leung KS, Chan CW, Fu LLK, Rosier R. 1999. Enlargement of remaining patella after partial patellectomy in rabbits. Med. Sci. Sports Exerc. 31(4): 502-506.
  35. Leung KS, Qin L, Leung MCT, Fu LLK Chan CW. 1999. Partial patellectomy induces decrease in proteoglycans content in the remaining patellar articular cartilage. An experimental study in rabbits. Clinical and Experimental Rheumatology 17:597-600.
  36. Kong SK, Suen YK, Chan YM, Chan CW, Choy YM, Fung KP, Lee CY. 1996. Concanavalin A induced apoptosis in murine macrophages through Ca2+-independent pathway. Cell Death and Differentiation 3: 307-314
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會議論文 Conference Paper

  1. Chau DK, Yang W, Choi AY, Leung WN, Chan CW. Sulforaphane Improved Social Communication Impairment with Upregulation of GABAergic Pathway in Cerebral Cortex of Valproic Acid Induced Autism The International Meeting for Autism Research IMFAR 2017. 10-13 May, San Francisco, California, USA
  2. Ma SY, Yang W, Chau DKF, Chan CW. Reduced expression of chemokines in experimental model of valproic acid induced autism. The 14th Asia Pacific Multidisciplinary Meeting for Nervous System Diseases, Brain 2017. 5-7 Jan 2017, Hong Kong.
  3. Chau DK, Yang W, Choi AY, Leung WN, Chan CW. Sulforaphane Improved Social Communication Impairment in Valproate Induced Autistic Mice with Up-Regulation of BDNF and NR2B in Cerebral Cortex. The International Meeting for Autism Research IMFAR 2016. 11-14 May, Baltimore, Maryland USA
  4. Chan CW. Chau KF, Yang W, Leung WN. The Effect of Sulforaphane on Valproic Acid on Mice Model of Autism. The 9th Pong Ding Yuen International Symposium on Traditional Chinese Medicine, 5-6 Dec 2015, Hong Kong
  5. Choi AY, Xian JW, Leung WN, Lau CB, Chan CW. Neuroprotective effect of Gastrodia-Uncaria water extract against reperfusion injury during cerebral ischemia via suppression of endoplasmic reticulum stress. The 11th International Postgraduates Symposium on Chinese Medicine, 14 Aug 2015, Hong Kong
  6. Zhang Z, Cheung HY, Leung WN, Chan CW. 2015. Effect of osthole, a Fructus Cnidii-derived nature coumarin, on osteogenesis and bone healing in mice. The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine. 22-24 July, Republic of Singapore.
  7. Xian JW, Huan T, Li L, Leung WN, Chan CW. 2015. Effects of Gastrodia elata and Uncaria rhynchophylla Water Extract on Cerebral Ischemic Rat Revealed by LC-FTICR-MS Metabolomics Approach. The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine. 22-24 July, Republic of Singapore.
  8. Cheung JH, Ip M, Hung LK, Leung WN, Leung KW, Chan CW. 2015. Sonodynamic antimicrobial effect of curcumin in mouse model of post-traumatic Staphylococcus aureus-infected femoral osteomyelitis. European Cells and Materials eCM XVI: Implant Infection. 24th - 26th June 2015, Davos, Switzerland. European Cells and Materials Vol. 30. Suppl. 2, 2015 (page 46)
  9. Choi AYT, Xian JW, Chan CW 2015. The Neuroprotective Effect of Gastrodia-Uncaria Water Extract on Oxygen Glucose Deprivation/Reperfusion against ER Stress in Neuron-like Neuroblastoma Cell Line". the Hong Kong Inter-University Postgraduate Symposium on Life Science 2015, 1 pgs. 2015.05.23.
  10. Zhang Z, Cheung HY, Leung WN, Li G, Chan CW. 2015. Osthole, an Anabolic Small Molecule, Enhances Bone Regeneration in Fracture Healing. The 61th Annual meeting of Orthopaedic Research Society, 28-31 March, Las Vegas, Nevada, USA.
  11. Dan X, Wong JH, Fang EF, Chan CW, Ng TB. Purification, Characterization and Anti-osteocarcinoma Study of a Novel Hemagglutinin from the Northeast China Black Beans. Experimental Biology 2015 p.401 (Abstract no.: D188 945.11). Boston, United States of America, 2015.03.28.
  12. Zhang Z, Cheung HY, Leung WN, Chan CW. 2014. Osteopromotive effect of Cnidium monnieri derived coumarin, osthole through cAMP signalling. International Symposium on Free Radical, Chinese Medicine & Translational Medicine. 15-16 Nov, Hong Kong.
  13. Zhang Z, Cheung HY, Leung WN, Chan CW. 2014. Cnidium monnieri Derived Coumarin Osthole Enhanced Fracture Healing. International Symposium on Free Radical, Chinese Medicine & Translational Medicine. 15-16 Nov, Hong Kong
  14. Xian JW, Huan T, Chau KF, Li L, Chan CW. 2014. Preclinical study of metabolomic profile of cerebrospinal fluid in Gastrodia elata and Uncaria rhynchophylla water extract treated cerebral ischemia in rat model International Symposium on Free Radical, Chinese Medicine & Translational Medicine. 15-16 Nov, Hong Kong.
  15. Zhang Z, Chan CW. Effect of Osthole on Osteogenesis and Bone Fracture Healing. 2014. European Calcified Tissue Society PhD Training Course and 6th International Workshop on Advanced in the Molecular Pharmacology and Therapeutics of Bone and other Musculoskeletal Diseases Joint Session. 28 June to 2 July, Oxford, United Kingdom.
  16. Zhang Z, Cheung HY, Wong YM, Leung WN, Chan CW. 2014. Osthole Enhances Osteogenesis in Preosteoblasts via cAMP/PKA Pathway. The 60th Annual meeting of Orthopaedic Research Society, 15-18 March, New Orleans, Louisiana, USA.
  17. Chan CW, Xian JW, Leung WN, Lau BS. 2013. Neuroprotective Effect of Two-Herbs Water Extract Against Oxygen Glucose Deprivation–Induced Injury in PC12 Cell. Cerebrovascular Diseases 35 (suppl 3): 545-545. Abstract 485.The 22nd European Stroke Congress, 28-31 May 2013, London, United Kingdom.
  18. Xian, JW, Chan CW, Lau BS, Koon CM, Ko CH, Leung WN. Neuroprotective effect of herbal extract containing Gastrodiae Rhizoma and Uncariae Ramulus cum Uncis on middle cerebral artery occlusion in rat. Cerebrovascular Diseases 35 (suppl 3): 543-544. Abstract 482. The 22nd European Stroke Congress, 28-31 May 2013, London, United Kingdom.
  19. Xian JW, Chan CW, Leung WN, Li MY. Borneol enhanced permeability of L-DOPA across blood-brain barrier- potential to lower dosage of L-DOPA to treat Parkinson's disease. The 11th International Conference on Alzheimer's and Parkinson's Diseases, 6-10 Mar 2013, Florence, Italy.
  20. Xian JW, Chan CW, Lau CBS, Koon CM, Ko CH, Leung AWN. 2012. Neuroprotective Effects of Tianma Gouteng Water Extract on NGF Treated PC12 Cells Injured by Oxygen-Glucose Deprivation and Reperfusion. The 8th International Postgraduates Symposium on Chinese Medicine, 16 Aug 2012, Hong Kong
  21. Xian JW, Chan CW, Lau CBS, Koon CM, Ko CH, Leung AWN. 2012. Neuroprotective Effect of Tianma Guoteng water extract against oxygen-glucose deprivation-Induced Injury in PC12 Cell Line. The Hong Kong International Integrative Medicine Conference 2012, 6-8 July 2012, Hong Kong.
  22. Xian JW, Chan CW, Lau CBS, Koon CM, Ko CH, Leung AWN. 2012. Neuroprotective Effect of Herbal Water Extract from Gastrodiae Rhizoma and Uncariae Ramulus Cum Uncis against Oxygen-Glucose Deprivation-Induced Injury in PC12 Cell Line. The 9th Asia Pacific Multidisciplinary Meeting Nervous System Diseases (Brain 2012 Symposium), January 13-14, 2012, Hong Kong.
  23. Luk HK, Lai YM, Qin L, Chan CW, Liu Z, Huang YP, Zheng YP. 2011.Ultrasonic Evaluation of Bone Callus Growth in a Rabbit Tibial Distraction Osteogenesis Model. International Conference of Biomedical Engineering and Technology (ICBEST 2011), September 28-30, 2011, Singapore.
 

Book Chapters

  1. Chan CW, Qin L. “Undecalcified histology of hard tissue implanted with calcium phosphate based ceramics” in “A Practical Manual for Musculoskeletal Research” ed by Leung KS, YX Qin, Cheung WH, Qin L. Aug 2008, World Scientific Publishing Company, Singapore, pp249-276.
  2. Chan CW, Leung KS. “Distraction Osteogenesis Model” in “A Practical Manual for Musculoskeletal Research” ed by Leung KS, YX Qin, Cheung WH, Qin L. Aug 2008, World Scientific Publishing Company, Singapore, pp381-400.
  3. Chan CW, Cheng JCY. “Posterior Spinal Fusion Model” in “A Practical Manual for Musculoskeletal Research” ed by Leung KS, YX Qin, Cheung WH, Qin L. Aug 2008, World Scientific Publishing Company, Singapore, pp441-456.
  4. Chan CW, Cheng JCY, Yeung HY, Qin L. “Bio-imaging technologies in studying bone-biomaterial interface: Applications in Experimental Spinal Fusion Model” in “Advanced bioimaging technologies in assessment of the quality of bone and scaffold materials” ed by Qin L, Genant HK, Griffith J and Leung KS. Sep 2007, Springer, Heidelberg, Germany pp331-351.